I've been a long time supporter of Lou, but I think he cost us the game today with a couple decisions.  If nothing else, they were very curious moves. 

First, with runners on second and third, he walks the number eight hitter to get to the pitcher.  So unless the pitcher hits into a double play, the best you can hope for is pitching to the number nine and then the leadoff hitter with the bases loaded.  In effect, you're walking the number eight hitter to pitch to the leadoff man.  Naturally, with the funk the Cubs are in, the worst possibility happens with the pitcher getting a 2-run single.  I don't blame Lou for that, but who knows what would have happened if he pitched to the number eight hitter.

Then, the inning after Lilly gives up three runs, he comes to bat with a runner on first and no out, behind by three runs.  Lou lets him bat and he sacrifices.  Why not pinch hit for him?  You need at least four runs to win the game.  Granted, the Padres didn't exactly light Lilly up when they scored the three runs, but it was the sixth inning and the way the Cubs have been hitting, the chances of them getting many more scoring opportunities were slim.